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pharmacology

Routes of Medication Administration

Medications are given via various routes — oral, IM, SC, IV, topical, and more. Each route has correct technique, sites, and absorption characteristics.

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Key Points to Know

What you must know about Routes of Administration

1

Common routes: oral (PO), sublingual, intramuscular (IM), subcutaneous (SC), intravenous (IV), topical, rectal, inhalation.

2

IM injections are given at a 90° angle; common sites include ventrogluteal and deltoid.

3

Subcutaneous injections are given at a 45–90° angle into fatty tissue (e.g., abdomen).

4

IV route has the fastest onset because it enters the bloodstream directly.

5

Intradermal injections (e.g., Mantoux/BCG) are given at a 10–15° angle.

6

The ventrogluteal site is preferred for IM injections as it avoids major nerves and vessels.

NMCN Exam Tips

How this topic appears in the NMCN exam

IM = 90°, SC = 45–90°, intradermal = 10–15° — memorise the angles.

IV route has the most rapid onset of action.

Ventrogluteal is the safest IM site in adults.

The vastus lateralis is the preferred IM site in infants.

Practice Question

Test yourself

At what angle should the nurse insert the needle when giving an intramuscular injection?

A.10–15 degrees
B.30 degrees
C.45 degrees
D.90 degrees✓ Correct

Explanation

Intramuscular injections are administered at a 90-degree angle to ensure the medication reaches the muscle. Subcutaneous injections use 45–90 degrees and intradermal injections use 10–15 degrees.

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